Research Article

꽃송이버섯(Sparassis latifolia) 추출물 소수성 분획의 항암 활성


In vitro anti-cancer activity of hydrophobic fractions of Sparassis latifolia extract using AGS, A529, and HepG2 cell lines

최문희, 한효경, 이용조, 조한교, 신현재

피인용수 : 0(자료제공 : 네이버학술정보)



The use of mushrooms has immense potential in many diverse applications. Until now, more than 3,000 species are consumed around the world, and more than 100 have shown promising clinical activity against cancer and other chronic diseases. Sparassis latifolia (formerly S. crispa) is an edible mushroom that harbors β-glucan reported to possess immunostimulatory and anticancer properties. However there have been no reports on the anticancer activity of hydrophobic fractions of S. latifolia. In this study, the anticancer activities of S. latifolia extract and hydrophobic fractions were investigated using AGS (stomach cancer), A529 (lung cancer), and HepG2 (liver cancer) cell lines. In cytotoxicity results of A529 cells, fractions of A2, A3, A4, A6, A7, A8, A9, and A10 in all 12 fractions show low IC50 values. For HepG2 cells, A7 fraction results in the lowest IC50 value while A7, A8, and A11 fractions show low IC50 values in AGS cells. S. latifolia extract lead to low cell viability in cancer cells, compared to positive control of paclitaxel. A compound with molecular weight of 181 were detected using HPLCMS but not identified yet. As a result, the hydrophobic fractions of S. latifolia EtOH extract would be a possible candidate as natural anticancer agents in the future.


 재료 및 방법
  Sparassis latifolia extract preparation and fraction
  Thin layer chromatography(TLC)
  DPPH radical scavenging
  High performance liquid chromatography-Mass spectrometer(HPLC-MS) analysis
  Cell culture
  Anticancer activity measurement
 결과 및 고찰
  꽃송이버섯 추출물의 소수성 분획물 준비와 분석
  DPPH radical scavenging activity
  Anticancer activity measurement
 감사의 말씀


  • 최문희 Moon-Hee Choi. 조선대학교 대학원 화학공학과
  • 한효경 Hyo-Kyung Han. 동국대학교 약학대학 약학과
  • 이용조 Yong-Jo Lee. 조선대학교 대학원 화학공학과
  • 조한교 Han-gyo Jo. 조선대학교 대학원 화학공학과
  • 신현재 Hyun-Jae Shin. 조선대학교 대학원 화학공학과


자료제공 : 네이버학술정보

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