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The purpose of this study was to investigate the effect of dietary supplementation of sea tangle (Laminariajaponica) on the blood glucose and lipid metabolism in streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley ratswere divided into 3 groups fed control, sea tangle powder (15%, w/w), or sea tangle water extract (4%, w/w) diet. Diabeteswas induced by a single injection of STZ (60mg/kg, i.p.) in citrate buffer. The animals were fed each of the experimental dietfor 13 weeks. Serum insulin was increased by dietary supplementation of sea tangle in diabetic rats. Dietary sea tanglereduced blood glucose level of diabetic rats compared to the diabetic rats fed control diet. Dietary sea tangle also reduced theserum total cholesterol, low density lipoprotein (LDL)-cholesterol, and triglyceridein the diabetic rats. While hepatic lipidswere reduced, fecal excretion of lipids was increased by supplementation with dietary sea tangle in the diabetic rats. Theseresults indicate that dietary sea tangle decreased blood glucose andimproved lipid metabolism in STZ-induced diabetic ratsand this effect might be exerted by increases in serum insulin and fecal excretion of lipids.