earticle

영어

Propionibacterium acnes is the predominant organism in sebaceous regions of the skinand is thought to play animportant role in the pathogenesis of inflamed lesions. Antibacterial compounds against P. acnes were isolated from theethanol extract of Kaempferia pandurata Roxb. and identified as panduratin A and isopanduratin A. Minimum inhibitoryconcentration (MIC) and minimum bactericidal concentration (MBC) of panduratin A for P. acnes were 2 and 4µg/mL,respectively, while those of isopanduratin A were 4 and 8µg/mL, respectively. The time-dependent killing effect showed thatpanduratin A and isopanduratin A completely inhibited the growth of P. acnes at 4 and 8µg/mL in 48hr, respectively.Panduratin A and isopanduratin A demonstrated high antibacterial activities not only against P. acnes but also other skinmicroorganisms. The results suggest that panduratin A and isopanduratin A could be employed as natural antibacterial agentsto inhibit the growth of acne and skin disease causing microorganisms.