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논문검색

Purification and Identification of Squalene Synthase Inhibitor Isolated from Fermented Soybean Paste

원문정보

Choi, Sung-Won, Kim, Dong-Seob, Hur, Nam-Youn (, Park, Cheon-Seok, Baik, Moo-Yeol

한국식품과학회 Food Science and Biotechnology Volume 14 Number 1 2005.02 pp.89-93
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

Squalene synthase (SQS) inhibitors were screened from various plants and food extracts. Effective SQS inhibitor was purified from fermented soybean paste using ethanol extraction, HP-20 column chromatography, ethyl acetate extraction, silica gel column chromatography, and crystallization. Through UV spectrometry, 1H NMR, 13C NMR, and mass spectrometry, SQS inhibitor was identified as daidzein with molecular mass of 254 and molecular formula of C15H10O4. Daidzein showed IC50 value of 50 nmol/L against SQS, confirming its potential as therapeutic agent for hypercholesterolemia.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

저자정보

  • Choi, Sung-Won Green Biotech Co. Ltd.
  • Kim, Dong-Seob Department of Food Science, Milyang National University
  • Hur, Nam-Youn ( Department of Food and culinary, Osan College
  • Park, Cheon-Seok of Life Sciences and Resources, Kyung Hee University
  • Baik, Moo-Yeol Institute of Life Sciences and Resources, Kyung Hee University

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자료제공 : 네이버학술정보

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