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Background: The purpose of this study was to compare an experimental group that received extracorporeal shock wave therapy (ESWT) and IASTM technique together with a control group that received ESWT and self-stretching exercise together to determine which treatment is more effective for muscle pain in patients with myofascial pain syndrome of the upper trapezius muscle. Methods: Twenty subjects with upper trapezius pain due to myofascial pain syndrome participated in the study. They were randomly divided into 10 experimental group and 10 control group. Subjects were conducted for 4 weeks, 3 days a week. The experimental group was subjected to radial type extracorporeal shock wave therapy 2000 times at an intensity of 5 Hz, and 2.0 bar once, and graston technique for 15 minutes one day. The control group was subjected to extracorporeal shock wave therapy with same, and upper trapezius self-stretching exercise for 15 minutes one day. All subjects measured and compared shoulder pain index with pressure pain threshold (PPT), Constant and Murley scale (CMS) pain index before and after the experiment. This study statistically analyzed the results of various experiments using Windows SPSS ver. 18.0, IBM, USA. Results: After the experiment, the experimental group decreased significantly in PPT of the neck-shoulder muscle and CMS pain index increased significantly. But control group was no significant difference. Conclusion: Though these results, extracorporeal shock and graston technique was decreased pain. Thus, extracorporeal shock wave therapy and graston technique is expect to be used as a variety of treatments to reduce shoulder pain as a cause of myofascial syndrome.