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Background: This study aimed to examine the effectiveness of role-play in dental hygiene education by analyzing learners’ perceptions and experiences of role-play classes. Methods: Role-play was used as a teaching method to run dental medical communication and practice classes for 31 3rd graders in the Department of Dental Hygiene to investigate the learner’s perception of role-play classes, effectiveness of the classes, and learner’s perception of the experience. The Mann-Whitney U test was used to analyze the differences in learners’ perceptions of the role-play classes according to the main characteristics related to dental health communication education. Results: The correlation coefficient between awareness of dental communication education (4.74 ± 0.35) and awareness of role-play classes (4.44 ± 0.48) was an Rs of 0.634, showing a significant positive correlation (p <0.001). Conclusion: Learners recognized that dental hygiene communication competency is important for dental hygienists. In addition, a strategic teaching design is necessary to reduce the learner’s burden on role-play considering the learner’s experience, which is perceived as a disadvantage of role-play.