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Purpose: This study investigated the relationship between satisfaction with fundamental nursing skills practicum, confidence in fundamental nursing skills performance and learning flow, and examined factors influencing satisfaction with practicum programs of fundamental nursing skills in face-to-face and online classes for nursing students amid COVID-19. Methods: The subjects of the study were 229 junior nursing students from two colleges of nursing located in D and C city, respectively. The collected data were analyzed with descriptive statistics, independent t-test, ANOVA, Kruskal-Wallis test, Pearson’s correlation and hierarchical multiple regression, using SPSS/WINdows 23.0. Results: The subjects’ satisfaction with practicum showed a high positive correlation with confidence in performance (r=.55, p<.001) and learning flow (r=.70, p<.001) in face-to-face classes, and their satisfaction with practicum showed a high positive correlation with confidence in performance (r=.56, p<.001) and learning flow (r=.73, p<.001) in online classes. The factors affecting the subjects’ satisfaction with practicum were learning flow (β=.51, p<.001) and confidence in performance (β=.30, p<.001) for face-to-face classes, and motivation for application (β=.14, p=.034), learning flow (β=.58 p<.001) and confidence in performance (β=.19, p=.015) for online classes. These factors explained 53% and 60% of the satisfaction with practicum in face-to-face classes (F=23.07, p<.001) and online classes (F=20.66, p<.001), respectively. Conclusion: Learning flow and confidence in performance should be considered when developing learning strategy programs to improve nursing students’ satisfaction with fundamental nursing skills practicum in both face-to-face and online classes.