Original Article

비스포스포네이트 제제 관련 관절통 및 근육통에 대한 지역 약국 약사 및 환자 능동적 모니터링


Arthralgia and Myalgia Associated with the Use of Bisphosphonate : An Active Monitoring Study

송정우, 박소희, 윤동원, 이모세, 이정민, 김나영, 김영욱, 이주연, 신주영

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Objective: We investigated arthralgia and myalgia associated with the use of oral bisphosphonate (BP) by conducting a survey of patient. Methods: The pharmacists conducted a survey between 1 Oct 2019 and 30 Sep 2020 among patients who were dispensed BP in community pharmacies to assess their demographic and medical characteristics, and their experiences with, and process for pain. Logistic regression analyses were performed to find the risk factors associated with the pain, and the odds ratios (OR) and 95% confidence intervals (CI) were determined. Results: A total of 160 patients who used BP participated in the survey (74 [46.3%] used risedronate; 61 [38.1%] used alendronate; 23 [14.4%] used ibandronate), and 20 (12.5%) of them experienced pain. Significant statistical differences of the characteristics between patients who experienced pain or not were observed regarding menopause, and parity. Compared with women who had one or two parity, women who had more than three parity were associated with the decreased risk of pain (OR, 0.24; 95% CI, 0.04-0.98). Moreover, steady exercise was associated with the decreased risk of pain compared to less exercise (OR, 0.37; 95% CI, 0.14-0.98). Conclusion: Our findings suggest that the risk of pain in BP-treated patients might be different regarding the different ingredients of BP, and dosing frequency. This survey highlights a need for a further safety research to understand the factors influencing the pain associated with the BP treatment.


연구대상 및 방법
연구대상 및 과정
연구설계 및 방법
연구 결과
응답자 기본 특성 및 BP제제 관련 특성
BP제제 성분별 사용 현황 및 통증 발생 여부
통증 발생의 영향 요인
환자의 증상
고찰 및 결론


  • 송정우 Jung-woo Song. 성균관대학교 약학대학
  • 박소희 So-Hee Park. 성균관대학교 약학대학
  • 윤동원 Dongwon Yoon. 성균관대학교 약학대학
  • 이모세 Mo-Se Lee. 대한약사회 지역의약품안전센터
  • 이정민 Jung-Min Lee. 대한약사회 지역의약품안전센터
  • 김나영 Na-Young Kim. 대한약사회 지역의약품안전센터
  • 김영욱 Young-Wook Kim. 대한약사회 지역의약품안전센터
  • 이주연 Ju-Yeun Lee. 서울대학교 약학대학
  • 신주영 Ju-Young Shin. 성균관대학교 약학대학


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