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Purpose: This study was a descriptive methodological study to develop protocols for school health practice to manage health problems of primary school students effectively. Methods: The protocols were verified by 12 experts and 10 health teachers, respectively, to secure a two-step content validity. Results: The main 8 health problems of primary school students were headache, abdominal pain, musculo-skeletal, respiratory, circulatory, ophthalmic, and oral-dental problems, and fever. The developed protocols consist of 8 algorithms, which are to help decision making in the course of assessing health problems and to identify and link related factors and associated symptoms, 8 school nursing records based on the Omaha classification system, and the list of 441 links between nursing assessment and nursing intervention. Conclusion: The use of the protocols is expected to make it easier for health teachers to apply the nursing process in solving the health problems of primary school students and supporting the rational decision making process, eventually improving the quality of primary school health. Repeated studies for protocol standardization as well as studies dealing with various health problems not included in the protocols should be performed for the development of school health practice protocols.