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Purpose : This study was conducted to analyze the factors that influence industrial health practices by recognizing chemical handling workers' Material Safety Data Sheets and to contribute to efficient health management of chemical handling workers. Methods : A total of 207 workers at chemical industrials were included in the study. The questionnaire included items on recognition of material safety data sheets, and implementation of industrial health. Results : The multi-linear regression analysis conducted to identify factors that affect industrial health practices showed that the factors that affect industrial health practices were significant factors such as job status, ease of access to material safety data, experience in use, and experience in training related to chemicals. Conclusion : In order to enhance industrial health practice of chemical workers, education and countermeasures should be developed to enhance utilization of chemical safety and health data since material safety health data are provided and the experience of using it has the greatest impact. In addition, various measures should be developed to enhance industrial health practice to protect the health of workers from the harmful risks of chemicals, as the level of industrial health practice by workers can be improved to help them habituate safe work.