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Objectives : This study develops a salutogenic program and examines its effects on the sense of coherence, acculturative stress, and quality of life of married immigrant women. Methods : The salutogenic program was developed based on Antonovsky's Salutogenic Model, and the study design was a nonequivalent control group pre-post test design. The participants were married immigrant Chinese (n=30) and Vietnamese (n=31) women, who were assigned to either an experimental group (n=29) or a control group (n=32). The data were analyzed using the χ²-test, t-test, Fisher's exact test, and repeated measures ANOVA, and the IBM SPSS for Windows (version 20.0) program was used to perform the analysis. Results : Compared to the control group, the sense of coherence (F=52.05, p 〈.001) and quality of life (F=6.95, p=.002) were significantly improved in the experimental group, and the acculturative stress (F=24.64, p〈.001) in this group significantly decreased after implementing salutogenic program. Conclusions : These findings indicate that a salutogenic program is an effective intervention for married immigrant women. The study suggests that such programs can be applied to married immigrant women at public health or multicultural family support centers to improve their sense of coherence and quality of life.