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Purpose: The purpose of this study was to identify the moderating effect of leisure satisfaction on the relationship between job stress and job satisfaction. Methods: A cross-sectional study was performed with 292 nurses having experienced shift work at least for 6 months. Data were collected from August to September in 2014. Descriptive statistics, t-test, correlation coefficient, and hierarchical regression analysis were performed. Results: The study showed that job satisfaction was significantly correlated with job stress (r=.-320, p<.001) and leisure satisfaction (r=.317, p<.001). Leisure satisfaction had a significant moderating effect on the relationship between job stress and job satisfaction (F=25.087, p<.001). Conclusion: This study concluded that the role of leisure satisfaction may moderate the relationship between the two. That is, the nurses who perceived higher satisfaction on their leisure life tend to have higher satisfaction to their job even in stress situation. Therefore, the strategies for improving leisure satisfaction are needed to increase job satisfaction in stressful conditions.