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Objectives : The purpose of this study was to explore diverse factors of patients with periodontal diseases, make comprehensive and pluralistic assessment of relevant factors, construct a hypothetical model, including direct and indirect paths, and test goodness-of-fit of the model. Methods : TRaw data were used from the sixth Korea National Health and Nutrition Examination Survey for the first and second years which was conducted from January 2013 to December 2014. Excluding current patients with cancer which could severely affect the quality of life among patients with periodontal diseases who were between 40 and 64 years of age, a total of 1,555 patients were included and finally analyzed in this study. Results : Among the factors affecting the quality of life, health perception had total effects through direct effects and functions had indirect and total effects through the channel of health perception. Conclusions : In oral health programs for the middle-aged, it is necessary to have preventive interventions in oral health; in particular, it is necessary to provide intervention programs that can improve health perception and relieve functional restrictions.