원문정보
Effects of Strawberry Plant Body Extracts on Whitening and Anti-Wrinkle
초록
영어
In this study, we investigated effects of the Strawberry plant body (SPB) extracts on the improvement of whitening and wrinkle. We confirmed effects of SPB extracts on UVB-exposed hairless mice to measure changes of skin conditions. The cream containing SPB extracts significantly decreases erythema index and melanin value on UVB-exposed hairless mice. Also, transepidermal water loss (TEWL) was significantly decreased in experimental group using cream containing SPB extracts on UVB-exposed hairless mice. UVB irradiation induces the expression of matrix metalloproteases (MMPs) in skin tissue. The up-regulation of MMPs enhances degradation of collagen and induces skin aging. The cream containing SPB extracts significantly decreases contents of MMP-2 and MMP9 on UVB-exposed hairless mice. These results suggest that SPB extracts might be used as a ingradient for improvement of whitening and wrinkle on UVB-exposed skin.
목차
Ⅰ. 서론
Ⅱ. 연구방법
1. 추출
2. Tyrosinase inhibition assay
3. 동물실험
4. 자외선 조사 및 시료 처리
5. 멜라닌 양과 홍반 지수 측정
6. 경피수분손실량 측정
7. Matrix metalloproteinase-2,9 (MMP-2,9) 발현량 측정
8. 조직병리학적 평가(HE염색)
9. 통계처리
Ⅲ. 연구결과 및 고찰
1. 1. 딸기 식물체 추출물의 tyrosinase 효소 저해 효능
2. 멜라닌 양과 홍반 지수 변화
3. 경피수분손실량 변화
4. MMP 발현량 변화
5. 조직병리학적 변화
Ⅳ. 결론
참고문헌
