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RAW264.7 대식세포와 급성염증유발 동물모델에서 문관나무 종자유의 염증억제 효과

원문정보

Anti-Inflammatory Effects of Xanthoceras sorbifolia Seeds Oil on RAW264.7 Macrophages and TPA-Induced Ear Edema Mice

정혜정, 이기연, 홍수영, 허남기, 김희연

피인용수 : 0(자료제공 : 네이버학술정보)

초록

영어

This study investigated the anti-inflammatory effects of Xanthoceras sorbifolia of seeds oil on RAW264.7 macrophages and TPA (12-O-tetra decanoylphorbol-acetate)-induced ear edema mice. MTT assay method to measure cytotoxicity was formed in RAW264.7 cell. The anti-inflammatory effect was measured by ability to inhibit production nitric oxide (NO) in RAW264.7 cell. Hexane and eight-percent methanol fractions from Xanthoceras sorbifolia seeds oil did not show cytotoxicity. Hexane and eight-percent methanol fractions were showed significantly inhibitory effect on NO production. TPA-induced acute edema was developed in the mouse ears, and Xanthoceras sorbifolia seeds oil dissolved in acetone was applied to inflamed ears. It was found out that Xanthoceras sorbifolia seeds oil could significantly reduce th ear swelling, compared to the control. Overall results indicate that the Xanthoceras sorbifolia seeds oil has anti-inflammatory activity and could be used as a resource of anti-inflammatory materials.

목차

Abstract
 서론
 재료 및 방법
  실험재료
  종자유 추출
  문관나무 종자유의 정제
  문관나무 종자유 추출물의 제조
  세포독성 측정
  Nitric oxide 생성량 측정
  실험동물
  염증 유발 및 문관나무 종자유 처치
  귀 부종 측정
  통계처리
 결과
  세포독성 및 Nitric oxide 생성 저해 효과
  마우스 귀 부종 염증 억제 효과
 고찰
 결론
 감사의 글
 References

저자정보

  • 정혜정 Hye Jeong Jeong. 강원도농업기술원
  • 이기연 Ki Yeon Lee. 강원도농업기술원
  • 홍수영 Soo Young Hong. 강원도농업기술원
  • 허남기 Nam Ki Heo. 강원도농업기술원
  • 김희연 Hee Yeon Kim. 강원도농업기술원

참고문헌

자료제공 : 네이버학술정보

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