earticle

영어

Fermentation process could enhance biological activities, specifically antioxidant and antimicrobial properties by modifying naturally occurring constituents of isoflavons, saponins, phytosterols, and phenols. TLC and HPLC showed the increase of rutin and quercetin, quercitrin due to the fermentation of Houttuynia cordata. This study was aimed to investigate the effect of fermented Houttuynia cordata (FH) on the improvement of lipid metabolism in rats fed high fat diet. The levels of body weight, AST, ALT, total cholesterol, HDL-cholesterol, LDL cholesterol, triglyceride(TG) and atherogenic index(AI) were measured in serum. Malondialdehyde(MDA) was measured in liver homogenate. High fat diet fed rat markedly increased the levels of AST, ALT, total cholesterol, LDL cholesterol, TG, AI and MDA, and significantly decreased the levels of HDL-C. But FH and NFH(non-fermented Houttuynia cordata) pretreatment decreased levels of AST, ALT, total cholesterol, LDL cholesterol, TG, AI and MDA respectively and increased those of HDL-C. FH group showed the most ameliorated state of steatosis making the decrease of small lipid droplets and the improvement of vacuolar degeneration in liver tissue. These results showed the FH had the effects of anti-obesity in obese rat model.