원문정보
초록
영어
Water and ethanol extracts of 16 different Korean traditional oriental prescriptions used widely for prevention of degenerative arthritis were prepared and their total phenolic and total flavonoid contents were quantified. Additionally, antioxidant and anti-inflammatory activities of water, ethanol and enzyme-treated extracts were determined by in vitro assays. Total phenolic and total flavonoid contents of three extracts from the 16 different medicinal prescriptions varied from 10.03-78.03 and 0-16.24 mg/g, respectively. Among the three extracts of 16 different medicinal prescriptions tested, ‘Mahangeuigamtang’ showed the potent full term for DPPH (RC50=71.26, 27.33, 63.00 μg/mL) and full term for ABTS (RC50=21.11, 27.45, 152.11 μg/mL) radical scavenging activities, and its water and ethanol extracts exhibited significant cyclooxygenase-2 (COX-2) inhibitory activity (49.10 and 69.06%, respectively). Ethanol and enzyme-treated extracts of ‘Euieuiintang ’ exerted the strongest COX-2 inhibitory activity (68.23 and 75.05%, respectively). ‘Mahangeuigamtang’ and ‘Euieuiintang’ may be useful as potential therapeutic agents for treatment of degenerative diseases, such as inflammation and aging.
목차
서론
재료 및 방법
실험재료
시약
복합생약추출물 제조
총 폴리페놀함량 측정
총 플라보노이드 함량 측정
DPPH radical 소거활성 측정
ABTS radical 소거활성
COX-2 저해 활성 측정
통계처리
결과 및 고찰
총 폴리페놀 함량
총 플라보노이드 함량
DPPH radical 소거활성
ABTS radical 소거활성
COX-2의 저해활성
요약
감사의 글
문헌