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Purpose: The purpose of this study was to examine factors related to burnout of nurses at hemato-oncology wards. Methods: The participants were 134 nurses working at hematology-oncology wards in three tertiary general hospitals in Seoul and Gyeonggi Province. Data were collected using a structured questionnaire that consisted of personal characteristics, occupational stress, satisfaction and burnout. Using a SPSS/WIN 12.0 program, descriptive statistics, t-test, ANOVA, and stepwise multiple regression procedures were employed. Results: The mean score of burnout reported by the participants was 3.15 ± 0.50 (range 1~5), showing the highest scores in the area of physical burnout (3.53 ± 0.57). The satisfaction with nursing profession was found to be the most impact on the burnout of the hematology-oncology ward nurses (β=-.533), followed by occupational stress (β=.351) and years of clinical experiences (β=-.154). Conclusion: Given the findings, the sorts of strategies to increase the satisfaction with nursing profession and decrease their occupational stress are required, particularly for newly employed nurses.