earticle

영어

Recently, bio-based fuels and polymers have become important due to the increase of oil price and concerns about environmental pollution.
Gamma aminobutyric acid (GABA) is the non-essential amino acid, which has recently found its possible application for monomer of nylon 4, the biodegradable heat-resistant polymer. Because direct synthesis of GABA from unrelated carbon source such as glucose is hard to achieve, conversion of L-glutamate (MSG) into GABA by enzyme catalysis or whole cell reaction becomes important in an industrial point of view.
Several Lactobacillus strains have been reported to naturally convert MSG to GABA through α-decarboxylation of MSG catalyzed by pyridoxal phosphate-dependent glutamate decarboxylase. In this presentation, we report several recombinant bacteria system to achieve high conversion yield of MSG to GABA