earticle

영어

Xanthorrhizol, a sesquiterpene isolated from Curcuma xanthorrhiza Roxb., was used to investigate its effect onreducing the saliva and multi-species oral biofilms consisting of Streptococcus mutans, Streptococcus sanguis, and Actinomycesviscosus by anti-biofilm and confocal laser scanning microscopy (CLSM) assays. Xanthorrhizol exhibited significant anti-biofilm activity in the dose- and time-dependent manners. Exposure to 2 and 5µg/mL xanthorrhizol for 30min remained<50% of saliva and multi-species biofilms formed for 24hr. In addition, exposure to 10µg/mL xanthorrhizol for 30minreduced 65 and 77% of 24hr saliva and multi-species oral biofilms, respectively. CLSM results visually demonstrated thatxanthorrhizol reduced bacterial viability in the saliva and multi-species oral biofilms. These results suggest that C.xanthorrhiza Roxb. containing xanthorrhizol with strong anti-biofilm activity can be employed as a plant source for oral carefunctional foods.