원문정보
초록
영어
The medicinal use of mushrooms have been traditionally used the asian area. Some polysaccharides or polysaccharide-protein complexes from mushrooms are able to stimulate the non-specific immune system and to exert antitumor activity through the stimulation of the host defence mechanism. Antioxidative and other biological activity of some medicinal mushrooms have been reported. Oxidative stress is thought to play a central role in initiating and driving the signaling events that lead to cellular response following UV irradiation. UV irradiation of skin increases hydrogen peroxides and other reactive oxygen species (ROS) and decreases anti-oxidant enzymes. These features are also observed in chronologically aged human skin. In both cases, increased ROS production alters gene and protein structure and function, leading to skin damage. In addition, the transcriptional upregulation of MMPs can be mediated by the increased production of ROS. In human skin fibroblasts, it was reported that exogenously added H2O2 or O2- causes an increase in the MMP-1 mRNA levels. Therefore, the antioxidant and antiaging effects of Inonotus obliquus were investigated in oxidative stress-induced human dermal fibroblast.