earticle

영어

In the current study, inhibitory activity of 8 selected Korean edible plants of Lamiaceae family against α-glucosidases, prepared from rat small intestine acetone powder was evaluated. Total flavonoids and oxygen radical absorbancecapacity (ORAC) were also investigated. Methyl alcohol extracts of Scutellaria indica (SI) had the highest α-glucosidaseinhibitory activity relevant for potentially managing hyperglycemia, followed by Clinopodium gracile (CG) and Thymusquinquecostatus (TQ). These 3 species also showed significant antioxidant activity in ORAC system. The α-glucosidaseinhibitory activity of the extracts was compared to selected phenolics. Among the standard phenolics tested quercetin whichwas major flavonoid in the extracts had the highest α-glucosidase inhibitory activity. CG, TQ, and SI which had high quercetincontent and ORAC values also exhibited significant sucrase inhibitory activity. Results suggested that selected 3 KoreanLamiaceae species have the potential development of effective dietary strategy for postprandial hyperglycemia and oxidativestress-linked diabetes complications.