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Purpose: This study proposes preventive strategies for factors affecting the work impairment of international medical tourism coordinators. Methods: Data for this study were collected via an online questionnaire survey involving 296 international medical tourism coordinators in South Korea, considering the impact coronavirus disease 2019. The survey was conducted from 25th April 2022 to 22nd July 2022 and data were analyzed SPSS/WINdows software version 22, including statistical, reliability, factor and regression analyses. Results: This study focused on occupational stress, health problems and job efficacy among international medical tourism coordinators in medical tourism research. The main objective was to examine the factors that influenced their work impairment. Conclusion: This study emphasizes the importance of factors such as occupational stress, health problems and job efficacy in influencing work impairment among international medical tourism coordinators. The identified factors account for 30% of explanation power. An intervention program tailored to the characteristics of domestic and international medical tourism coordinators is recommended.