원문정보
초록
영어
We tried to evaluate genotoxicity. Three different mutagens, mitomycin C (MMC), 1-methyl-1-nitroso-N-methylguanidine (MNNG) and Nalidixic acid (NDA) were used to evaluate their toxicogenomic impacts on Escherichia coli. Different doses such as, sublethal, LC20 and LC50 and four testing time points, 5 min, 25 min, 45 min and 65 min were used. Commonly expressed genes as potential genotoxicity biomarkers on E. coli were obtained. By analyzing time-course expression data, distinct impacts of each chemical were pivotallized based on SOS resulted genes. And depending on time course expression, we can figure out different chemical effects based on SOS related genes. Clustering analysis of the DNA microarray gene expression data resulted in the presentation and visualization of functional classification and chemical-gene
network.