원문정보
초록
영어
Chiral epoxides have been used as a key intermediate for the synthesis of chiral biocompounds(1). They can be prepared by epoxide hydrolase-catalyzed enantiospecific biohydrolysis of racemic epoxides(2). The similar microsomal and microsomal EHs (smEH & mEH) of a zebra fish was characterized as a biocatalyst for the preparation of chiral epoxides and diols. The recombinant smEH and mEH have developed on the basis of bioinformatics and molecular
modeling. The recombinant marine fish EH from Mugil cephalus has also been developed by using RACE and PCR techniques. Marine microbial activity was identified from Sphingomonas sp. The characteristics features of the fish and marine EHs as a biocatalyst for preaparion of chiral epoxides were analyzed. Acknowledgment: This work was supported by the Marine and Extreme Genome Research Center Program, Ministry of Marine Affairs and Fisheries, Republic of
Korea.