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논문검색

Effect of rice hull on the suppression of mouse ascites carcinogenesis by a hot-water extract from the submerged-liquid culture of Agaricus blazei Murill

초록

영어

Anticarcinogenic effects of a hot-water extract (HWE) of the submerged-liquid culture of Agaricus blazei Murill, cultured in the rice hull (RH)-supplemented medium, was examined for the S-180 cell-induced mouse ascites carcinogenesis. The β-D-glucan, Brix, and mycelia weight of the HWE from the basal medium(BM)+1% RH culture were 59.8±1.5(㎎/100 ㎖), 4.1±0.1 (%), 6.0±0.5(g/100 ㎖), respectively, which were significantly enhanced as compared to those of
HWE from BM culture. The average life span of S-180 cells-induced mice treated with HWE from BM culture was 20.1 days, but it was extended to 30.1 days by HWE from the BM+1% RH culture, indicating 49.8% life extension was great effect of the RH. Four mice were survived in the group treated with HWE from the BM+1% RH culture at the termination of experiment, but no
mice was survived in group treated with HWE from the BM. These results suggest that when mushroom mycelia is cultured in submerged-liquid culture, RH could be an excellent ingredient to enhance both the growth of mushroom mycelia and anticarcinogenicity of the hot extract of the liquid cultures. This study was partly supported by the BK21 program of GNU.

저자정보

  • Byong Woo Lee Divesion of Applied Life Sciences, Graduate School, Gyeongsang National University
  • Young Suk Kim Divesion of Applied Life Sciences, Graduate School, Gyeongsang National University
  • Yun Ah Kim Divesion of Applied Life Sciences, Graduate School, Gyeongsang National University
  • Wook Jin Jang Divesion of Applied Life Sciences, Graduate School, Gyeongsang National University
  • M. A. Islam Divesion of Applied Life Sciences, Graduate School, Gyeongsang National University
  • Su Jeong Shim Divesion of Applied Life Sciences, Graduate School, Gyeongsang National University
  • Seon Min Lee Divesion of Applied Life Sciences, Graduate School, Gyeongsang National University
  • Jeong Ok Kim HK Biotech Co. Ltd.
  • Cherl Woo Park HK Biotech Co. Ltd.
  • So Young Kim Jinju International University
  • Yeong Lae Ha Divesion of Applied Life Sciences, Graduate School, Gyeongsang National University

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