원문정보
초록
영어
This work was undertaken to assess the protective effect of an isoflavonoid, calycosin-7-O-β-D-glucopyranoside (CG), isolated from Astragali radix (AR) on the pathogenesis of osteoarthritis (OA)-like lesion in a rebbit model. Methods: Nine rabbits underwent an anterior cruciate ligament and menisectomy transection of the rear knee joints to induce OA-like lesion. A negative control group treated with 200㎕ of 0.5% (v/v) DMSO, a positive control group treated with 200㎕ of 100μM
piroxicam, and a test group treated with 100㎍/500㎕ of CG, where the test agents were administered by injection once a week for 4 weeks starting from the third week. The synovial fluid was analyzed for the amounts of total proteins, glycosaminoglycans(GAG) and prostaglandin E2 (PGE2). Results: The total synovial fluid volume (P<0.05) was most strikingly reduced by the treatment with CG. Moreover, the CG treatment also significantly alleviated the OA-induced accumulation of prostaglandin(PG) (P<0.001)and total proteins(P<0.001) in the
synovial fluid. The histopathologic analyses revealed that the CG treatment reduced the severity of the OA-like stuctual damages in the cartilages.