Mussel adhesive proteins (MAPs) which tightly attach to the substratum have the strongest
adhesion force. Compare to other polymer-based adhesives, it can adhere to wet surfaces and
maintain flexibility. Moreover, the mussel adhesive proteins are hardly broken by harsh conditions such as turbulence, humidity, salinity, and tides. Mussel adhesive proteins as effective water-resistant bio adhesives, can attach to not only substratum but also plastic, metal and skin. Due to these advantages mentioned above, it can make various applications, especially biological adhesives. The important parts of biological adhesive applications are biocompatibility and immune responses.
Interestingly, the mussel adhesive proteins do not bring on immune responses. Moreover it can
degrade by itself, so the mussel adhesive proteins can be an environmentally bio-materials. Here, we studied recombinant DNA technology as a method to achieve mass production of mussel adhesive proteins.