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영어

In this study, astaxanthin production by P aracoccus sp. was optimized based on the Blaszczyk' s medium with surface response methodology. A screening test was first conducted on 5 medium components using a Plackett-Burman design, from which MgSO4 and yeast extract were identified as the significant factors affecting astaxanthin production. These significant factors were optimized by central composite design of experiments and response surface methodology, as 2.83 g/L MgSO4 and 7.02 g/L yeast extract, respectively. The expected
astaxanthin concentration with these optimized medium compositions were 0.925 mg/L. In flask culture, the experimentally obtained concentration of astaxantin was 1.021 mg/L, where it had been 0.4 mg/L before optimization.