earticle

영어

Alzheimer' s disease is the most common form of dementia, accounting for 50-60% of approximately 20-30 million dementia cases around the world. Neurofibrillary tangles containing hyperphosphorylated tau represents one of the principal pathological hallmarks of the brain of Alzheimer’s Disease (AD) patients. Although there are a lot of studies about tau and AD disease, it needs to be more cleared.
In this study, we carried out RT-PCR to confirm Tau and APP expression in transgenic mice expressing neuron-specific anolase (NSE)-controlled human wild-type tau (NSE/ htau23) and also compared cortex proteins of NSE/ htau23 transgenic mice with those of controlled mice by using the two-dimensional electrophoresis. As the results, we found several proteins which were
significantly changed in different stages of AD. Such proteins were expected to induce abnormal phosphorylation of tau, which are finally associated to neuronal degeneration in AD.