원문정보
초록
영어
Cardiovascular disease (CVD) is a major cause of mortality and morbidity. Every year, about 37 million people throughout the world die of CVD. It is mainly caused by a blockage that prevents blood from flowing to heart or the brain. The most common reason for blockage is a build-up of fatty deposits, inflammation and atherosclerotic plaques on the inner walls of blood vessels. It
is assumed that CVD related proteins will be released from the deposits or plaque on the inner wall of blood vessels. In this study, to identify the changed proteins for early diagnosis of CVD, protein profiles of human sera from non-diabetic CVD patients (n=20) were compared with those of healthy controls (n=30) by using the two-dimensional gel electrophoresis technique. As the
results, the differentially expressed spots in CVD patients were identified with electrospray ionization quadrupole time-of-flight (ESI-Q-TOF) mass spectrometry. Among the identified proteins, A is confirmed to be a possible candidates as biomarker for CVD.