원문정보
초록
영어
Among the high molecular weight components of higher fungi, polysaccharides have attracted attention recently in the enhancement of host defense mechanisms, which has been recognized as a possible means of immunomodulatory and antitumor effects without doing harm. Macrophages play a major role in host defense against infection and cancer. When pathogens cross an epithelial barrier, they are engulfed by phagocytosis of macrophages and are
digested by lysosomal enzymes, such as phosphatase, released from them. For these cellular events, an intracellular alteration such as signaling cascades has known to be accompanied by a connection from cell surface molecules including pattern-recognition receptors (PRRs) to the intracellular signaling machinery. So far, receptor type or nonreceptor-type tyrosine kinase, protein kinase C, phosphatidylinositol 3-kinase (PI3K)/Akt, and mitogen-activated protein kinase
(MAPKs), as well as transcription factors such as nuclear factor (NF)-kB and activator protein (AP)-1, have beeen reported to be the major components of the signaling machinery. Cordyceps militaris has been widely used due to its folkloric activities, which are not based on scientific studies. In this study, therefore, it was aimed to prove the action mechanisms of polysaccharides from C. militaris on macrophage-mediated innate immune responses.