원문정보
초록
영어
Some of natural products have been long used as a botanical medicine for anti-inflammation in korea. Inflammation is the complex biological response of vascularized living tissue to local injury. The function of inflammation is to enclose injury, destroy invading microorganisms and inactivate toxins. The process of inflammation, however, can potentially be harmful, such as
hypersensitive reactions, chronic inflammation and progressive organ damage.
Macrophages are considered to play essential roles in inflammation. When activated by endotoxin, macrophages produce Nitric oxide. The inhibitory effects of these natural products on NO production from lipopolysaccharide induced RAW 264.7 macrophages were measured. Among them, natural products with potent inhibition of NO production were selected, and then
iNOS expression was measured using RT-PCR. The goals of this research were to study the anti-inflammatory effects of extracts from natural product in RAW 264.7 cell line.