원문정보
초록
영어
To improve the functional properties of chitosan, carboxymehtylchitosan (CM-chitosan) was synthesized by chemical modifications. CM-chitosan, an important water soluble chitosan derivative, has many attractive chemical, physical and biological properties such as gel-forming capability, low toxicity, and good biocompatibility, all of which make it a promising biomaterial1).
In this study, we compared CM-chitosan with the other emulsifiers to emulsifying activity, and the optimum conditions for high emulsifying activity and stability of CM-chtiosan were investigated. Emulsifying activity of the CM-chitosan was investigated in various conditions such as concentration, water-oil ratios, pH and temperature. The emulsifying activity of CM-chitosan was 20% higher than of gelatin, bovine serum albumin, and Tween-80 as commercial emulsifier. The emulsifying activity of CM-chitosan solution was the highest at 1.5%, and was decreased with increasing concentration at above 1.5% of CM-chitosan. The optimum conditions of water-oil ratios. pH and temperature were 50% (w/v), pH 8.0 and 20℃, respectively. In these conditions, the emulsifying activity of CM-chitosan solution was 86%. The emulsion stability of CM-chitosan was higher than that of other commercial emulsifier. Moreover, CM-chitosan did not show any cytotoxic effect against MRC-5 cell lines.