원문정보
초록
영어
Two kinds of topical dosage forms of hinokitiol (HKL), namely vesicles and oil-in-water emulsions, were prepared. Behenyl trimethylammonium chloride and fatty acids were used as bilayer-forming materials of the vesicles, and oils were employed as oil phases of the emulsions. The substantivity of HKL in the preparations was evaluated in vitro using hairless mouse skins. After applying the preparations onto the skin and rinsing it, the amount of HKL left
on the skin was determined using high performance liquid chromatography. It was higher when HKL was encapsulated in cationic vesicles rather than in non-ionic vehicles, emulsions. In vivo hairgrowth-promotion effect of each dosage form was investigated, where the sample application onto the clipped backs of female mice (C57BL6) and the subsequent rinsing of the backs were
done once a day for 30days. Only HKL in the cationic vesicles had hair growth promotion effect, possibly due to the significant substantivity.