원문정보
초록
영어
Various antimalarial drugs are being synthesized and evaluated for their antimalarial activity to be used in combinational therapy. Pyronaridine is one of these antimalarial drugs that is currently under investigation. In this study, we have synthesized an 131I-labelled pyronaridine and studied its metabolism and mode of response in rabbits. Dynamic imaging studies in rabbits showed that the 131I-labelled pyronaridine was not concentrated in the thyroid for upto 30 min as that of the Na131I. Biodistribution studies on the blood, liver, heart, spleen, kidney and lung of rats revealed that the maximum percentage of the injected dose (% ID) and the percentage of the injected dose per gram organ weight (% ID/g) of 131I-labelled pyronaridine was found in the blood and liver when compared to the other organs even after 6 days of the drug administration. According to these results, this biological evaluation of 131I-labelled pyronaridine can be used as a simple, fast, efficient, and direct measure of an antimalarial drug activity.