earticle

영어

Thermo-sensitive hydrogels are commonly used in many biomedical and pharmaceutical applications, including tissue engineering and drug delivery systems. Due to their sensitivity to thermal stimulus, they have a great potential in site-specific controlled drug-delivery systems. A new class of injectable and bioabsorbable supramolecular hydrogels, which are formed from poly(ethylene oxide) (PEO) and α-cyclodextrin (α-CD), have been investigated for controlled
drug delivery. In this study, we examined the release profiles of several poorly water-soluble drugs from these new biodegradable hydrogels. Physically crosslinked hydrogels were prepared from mixed aqueous solutions of PEO and α-CD using a temperature-controlled gelation technique at various concentrations of both compounds. The drug release profiles of several drugs from hydrogels were determined in vitro via dialysis using high-performance liquid
chromatography.