원문정보
초록
영어
The purpose of this study was to develop nanoparticle which have a specificity at tumor site and multidrug resistant cancer cells. A cationic polymer/vitamin conjugated for preparation of the nanoparticles. The cationic polymer has cytotoxicity, but the nanoparticle from the conjugate slightly reduced the toxicity. However, there are still remained a toxicity. For this reason, the
nanoparticle was covered with biocompatible polysaccharide(BP) which can be easily degraded by an enzyme from tumor site.1) And the vitamin has a hydrophobicity, so the nanoparticle can loaded with hydrophbic anticancer drug.
Drug loaded nanoparticle was expected that MDR effect should be reduced, and the the cationic polymer increase a anticancer effect.2) The cytotoxicity of the nanoparticle measured by MTT assay depended on the enzyme concentration.
The interaction between the nanoparticle and cancer cells was observed by confocal microscopy as a function of BP concentration. The result indicated that BP can enhance the specificity of tumor site due to inhibit the internalization of the nanoparticle in the normal tissue.