earticle

영어

Atopic dermatitis (AD) in humans is a chronic pruritic inflammatory disease that fluctuates with remissions and progressions. It is considered that AD may be due to various genetic and environmental factors, a skin barrier, immune factors and stress (1); however, its exact etiology is unclear. Therefore, it is worthwhile to establish a suitable animal model to elucidate the pathogenesis of AD and to develop new approaches for therapy. Immune response and skin lesions, which are generally observed in patients with AD, have been indicated as major
diagnostic criteria (2, 3). Recently, animal models of AD, including NC/Nga mouse and hapten-induced mouse models, have received increasing attention. This study was designed to compare three mouse models for AD: 2,4-dinitrochlorobenzene (DNCB) induced NC/Nga model, DNCB induced Hairless model and DNCB induced BALB/c model. Result, DNCB induced NC/Nga model revealed AD-like severe skin lesions and the Hairless model revealed a
Th2-dominated immune response in serum. On the other hand, for the BALB/c model, it did not reveal skin and immune responses. In summary, the NC/Nga and Hairless models are mainly attributable to DNCB, and these models can be used as AD models.