earticle

영어

The present investigation was performed to evaluate the effect of hesperidin, a flavanone glycoside, on the antioxidant defense system and a lipid peroxidation against γ-radiation induced damage in rats. Exposure of the rats to γ-radiation (5 Gy) resulted in tissue damage characterized by significantly elevated levels of serum marker enzymes (AST, ALT, ALP, LDH, and CPK) and a decrease in their activities for the heart tissue. A γ-radiation induced oxidative stress was observed by the elevated levels of a lipid peroxidation and a decrease in the activities of the endogenous antioxidants (SOD, CAT, GPx and GSH) in the heart and kidney of the rats. Post-treatment with hesperidin (50 and 100 mg/kg, bw/day, orally) for 7 days following an exposure to γ-radiation significantly attenuated these changes when compared to the radiation exposed groups. Histopathological examination of the heart and kidney tissue of the rats exposed to a γ-radiation and treated with hesperidin also revealled minimal damage
when compared to those exposed to γ-radiation alone. These findings indicate the protective effect of hesperidin on a lipid peroxidation and the antioxidant tissue defense system during γ-radiation induced tissue damage in rats.