earticle

영어

Molecular chaperones are proteins that help the folding of other proteins, usually through cycles of binding and release, without forming part of their final native structure. The functional importance of molecular chaperones such as the calnexin, calreticulin, ERp57, and protein disulphide isomerase that are engaged in protein folding is summarized here. The relevance of the molecular chaperones in the context of Chinese hamster ovary cell engineering to enhance
the cell specific productivity (qp)1-2, in apoptosis engineering3 and protein quality control4 is discussed in detail with examples.