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영어
Text: Cell therapy using stem cells is a promising method to treat inveterate diseases like myocardial infarction and spinal cord injury. But there are some obstacles in the stem cell therapy, which include the problems in homing and fixing stem cells to desired site. In this
study, magnetic nanoparticles were used to overcome these challenges in therapeutic application of stem cells. Magnetic bio-nanoparticles were harvested from magnetic bacteria
strain Magnetospirillum magneticum AMB-1. They are 40-50nm diameter ferromagnetic nanoparticles and have lipid bilayer on their surface. These particles were added to culture
medium and they were introduced into Endothelial Progenitor Cell(EPC) by changing medium
to particle-contained one. It was observed that magnetic nanoparticle introduced cells moved
to specific direction on external magnetic field and fixed desired site.