원문정보
초록
영어
Spirulina extract is a possible candiate for cosmetic ingredients because it contains vitamin A, E and Calong with other strong antioxidatives. But its skin efficacy has not been studied well. Previously spirulina extracts fermented by Lactobacillus plantarumP23 and Bacillus subtilis TP6 were shown to have strong antioxidant activites analysed by DPPH methods. In addition, both extracts reduced significantly UV-induced TNF-aand IL-6 in cultured keratinocytes. In this study, anti-aging efficacy of the fermented spirulina extracts was investigated. The mechanism of
these skin aging are closely assosiated with MMPs(matrix metalloproteinases) activities. UV-induced MMPs cause connective tissue damage, as a result, skin become wrinkled and aged. Zymography was used to determine the expression of UV-induced MMPs. Also collagen synthesis was measured in cultured human dermal fibroblasts by a sircol assay. Treatment with fermented spirulina extract resulted in the increase of collagen synthesis and reduced the expression of UV-induced MMPs in human dermal fibroblasts in vitro. The results suggest that fermented spirulina extracts have a potential as anti-aging cosmetic ingredients.