원문정보
초록
영어
Thermosensitive polymers with a lower critical solution temperature (LCST) near or below
body temperature are of great interest for biomedical applications such as local drug delivery
and body temperature sensitive drug release1. The advantages of thermosensitive polymers for
drug delivery materials have been explained in terms of local delivery and controlled release of
drugs2.
We have studied biodegradable thermosensitive poly(organophosphazenes) bearing α-amino-ω-
methyl-poly(ethylene glycol) (AMPEG), some hydrophobic amino acid esters, and a
depsipeptide ethyl ester (ethyl-2-(O-glycyl)glycolate) as a hydrolysis sensitive moiety have
been synthesized. Most of the poly(organophosphazenes) synthesized showed sol-gel transition
properties in an aqueous solution.
The aqueous solutions of the present polymers were injected subcutaneously into rats, which
resulted in immediate gelation. The biocompatibility testing of the polymers has showed the
minimum or mild tissue reaction in rats. The anticancer agent, doxorubicin, loaded easily in the
polymers at low temperature was released over a month from the polymer gels in a controlled
rate. These gels will be expected to be useful for local delivery of protein and anticancer drugs.
In this study, we discuss thermosensitive properties and application of these poly(organophosphazenes) as drug carriers.