원문정보
초록
영어
Labisia pumila has been used for many generations by the Malay women as a post-partum medicine. The herb Kacip Fatima has long been regarded as the "queen" of Malaysian herbs. But its skin efficacy has not been studied yet. In this study, we have thus focused on finding anti-aging and anti-melanogenesis efficacy of the Labisia pumila extract. Extracts of Labisia pumila were analyzed for their antioxidant activities by DPPH (2,2-diphenyl-1-picrylhydrazyl) methods and found it has strong antioxidant activity. Treatment with the Labisia pumila extract enhanced collagen synthesis and inhibited the production of pro-inflammatory cytokines. Labisia
pumila extract protects cell damage induced by UVB. Collagen synthesis of human dermal fibroblasts treated with Labisia pumila is increased dose dependent manner. Labisia pumila extract showed the strongest anti-melanogenesis activity. Treatment with the Labisia extract inhibits α -melanocyte stimulating hormone induced melanin synthesis in B16F1 melanoma cells. However the Labisia extract did not inhibit mushroom tyrosinase activity in vitro. Instead internal tyrosinase activity was reduced significantly by the treatment of the Labisia extract, which suggested that Labisia extract suppressed the expression of tyrosinase gene. The results
show that the Labisia pumila extract has strong radical scavenging activity, anti-inflammatory activity and also restores collagen production by the UVB irradiated dermal cells. It also has strong inhibitory activity in melanogenesis. Taken together, the Labisia pumila extract has a good
potential as anti-aging and whitening agent for cosmetic ingredient.