원문정보
초록
영어
Medicinal higher fungi such as Cordyceps sinensis and Ganoderma lucidum are used as an
alternative medicine remedy to promote health and longevity for people in China and other
Asian regions since ancient times. Nowadays there is an increasing public interest in the
secondary metabolites of those higher fungi for discovering new drugs or lead compounds
around the world. Current research in drug discovery from medicinal higher fungi involves a
multifaceted approach combining mycological, biochemical, pharmacological, metabolic,
biosynthetic and molecular techniques. In recent years, many new secondary metabolites from
higher fungi have been isolated and are more likely to provide lead compounds for new drug
discovery, which may include chemopreventive agents possessing the bioactivity of
immunomodulatory, anticancer, etc. However, numerous challenges of secondary metabolites
from higher fungi are also encountered including bioseparation, identification, biosynthetic
metabolism, and screening model issues, etc. Commercial production of secondary
metabolites from medicinal mushrooms is still limited mainly due to less information about
secondary metabolism and its regulation. Strategies for enhancing secondary metabolite
production during medicinal mushroom fermentation, such as a two-stage cultivation
technology combining liquid fermentation and static culture, will be demonstrated in this
presentation. Purification of ganoderic acids (bioactive secondary metabolites from
Ganoderma lucidum) and their antitumor mechanism study will also be shown.