earticle

영어

In Korea and many other developed countries, obesity is one of the most threatening health problems. However, there are only few good anti-obesity products in terms of effectiveness and safety. This study is to develop many edible, nontoxic agricultural food grade, biomaterials for development of side-effect free anti-obesity functional food or pharmaceutical products. For the development of the anti-obesity natural drug, the inhibitor of adipocyte differentiation is screened from Korean traditional medicinal plants. We will examine the inhibitory effect of raw material extracts on adipogenesis by oil red O staining, adipocyte differentiation related transcription factor expression, and lipid accumulation experiment. Finally, we will isolate and identify the active-compounds containing an anti-adipogenesis activity from selected plant extracts using open column chromatography and HPLC/MS.