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Cardiovascular disease (CVD) is the most common and serious complication of diabetes. In fact, about 65 percent of people with diabetes die of heart attack and stroke. For most people who do not have diabetes, heart disease speaks clear. Inadequate blood flow to the heart muscle causes chest pain, a pounding heartbeat, shortness of breath, sweating. In people with diabetes, however, heart disease often does not offer such clues, so they may not seek medical care until
noticeable and more serious complications have occurred. There are no specific biomarkers for the development of CVD with diabetes other than electrocardiogram or a nuclear stress tests. In this study, we have utilized two-dimensional electrophoresis to identify human serum protein markers for progressive CVD in type 2 diabetes patients, via comparisons of the serum
proteome in three experimental groups: healthy people (n=30), diabetic patients without CVD (n=30), with CVD (n=25). Several proteins were found to be significantly changed in comparison to these three groups. These results will be useful to identify potential biomarkers for the progression of CVD with diabetes.