원문정보
초록
영어
Silk fibroin also has a long history of use in a clinical application as a suture proving biocompatibility. Thus, it has been developed for use in biomaterials as films[1] and carriers for drug delivery[2,3]. In this report, a packed fibroin microsphere was prepared from W/O emulsion of a regenerated fibroin in a continuous oil phase[4]. Dried microspheres of 25.9 ± 9.2 μm in diameter were routinely produced from the W/O emulsion at the stirring speed of 600 rpm under the optimum concentrations of fibroin and detergent. However, biconcave forms of microspheres similar to red-blood cell were observed at the stirring speed of 800 rpm. Application of vacuum drying after the formation of the W/O emulsion yielded smaller microspheres of 10.8 ± 5.9 μm.
Tomography of the microsphere with FITC dye revealed a completely packed internal structure. No significant erosion or deterioration of the microspheres were observed after 11 days of trypsin treatment.