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논문검색

Comparison of immunomodulatory potential between mesenchymal stem cells derived from various human adult tissues

초록

영어

Mesenchymal stem cells (MSCs) may have immunomodulatory properties, which could suppress the immune response toward alloantigen by inhibiting T cell proliferation in mixed-lymphocyte reactions (MLRs). In this study, we have investigated the immunomodulatory potential of MSCs derived from various human adult tissues, including umbilical cord wharton’s jelly (WJ), cord blood (CB), adipose tissues (AT), and bone marrow (BM). Isolated and cultured MSCs were strongly positive for CD73, CD90, and CD105, and differentiated into mesenchymal derivatives such as osteoblast, adipocyte, and chondrocyte under appropriate culture condition. Moreover, we compared the suppressive effect of WJ-MSC, CB-MSC, AT-MSC and BM-MSC on PHA-induced T-lymphocyte proliferation. WJ-MSC, CB-MSC, and AT-MSC significantly suppressed T-cell activation in dose-dependent manner as BM-MSC. These results indicate that WJ-MSC, CB-MSC, or AT-MSC could be an alternative cell to BM-MSC for treatment of allogenic conflicts.

저자정보

  • Myoung Woo Lee Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine
  • In Keun Jang Biomedical Research Institute, LifeCord Inc.
  • Mal Sook Yang Biomedical Research Institute, LifeCord Inc.
  • Youngwoo Eom Biomedical Research Institute, LifeCord Inc.
  • Jong Eun Lee Biomedical Research Institute, LifeCord Inc.
  • Hyo Eun Kim Biomedical Research Institute, LifeCord Inc.
  • Young Jin Kim Biomedical Research Institute, LifeCord Inc.
  • Young Sook Yim Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine
  • Hye Ryung Kim Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine
  • Hye Lim Jung Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine
  • Keon Hee Yoo Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine
  • Hong Hoe Koo1 Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine

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