원문정보
초록
영어
Mesenchymal stem cells (MSCs) may have immunomodulatory properties, which could suppress the immune response toward alloantigen by inhibiting T cell proliferation in mixed-lymphocyte reactions (MLRs). In this study, we have investigated the immunomodulatory potential of MSCs derived from various human adult tissues, including umbilical cord wharton’s jelly (WJ), cord blood (CB), adipose tissues (AT), and bone marrow (BM). Isolated and cultured MSCs were strongly positive for CD73, CD90, and CD105, and differentiated into mesenchymal derivatives such as osteoblast, adipocyte, and chondrocyte under appropriate culture condition. Moreover, we compared the suppressive effect of WJ-MSC, CB-MSC, AT-MSC and BM-MSC on PHA-induced T-lymphocyte proliferation. WJ-MSC, CB-MSC, and AT-MSC significantly suppressed T-cell activation in dose-dependent manner as BM-MSC. These results indicate that WJ-MSC, CB-MSC, or AT-MSC could be an alternative cell to BM-MSC for treatment of allogenic conflicts.